Retinal Screening Study

Early detection of retina and optic nerve disease, using a very fast routine for evaluation of the pupil light reflex.

A method for early detection

The primary purpose of the retinal screening study is early detection of retina and optic nerve diseases, using a very fast routine for evaluation of pupil light reflex. The goal is to establish a procedure for timely diagnosis and treatment, before damage to the retina and optic nerve becomes irreversible. This methodology was developed for veterinary use by Dr. Grozdanić and his team, and demonstrates high accuracy in detecting many common retina and optic nerve problems in veterinary patients.

We also have a strong interest in early detection of autoimmune retinal diseases, with a specific focus on Sudden Acquired Retinal Degeneration Syndrome (SARDS). Dr. Grozdanić and his team pioneered the method for the detection of SARDS using a chromatic pupil light reflex test a decade ago.

In October 2016, Dr. Grozdanić and his team reported detection of SARDS in dogs that had completely normal day vision (American College of Veterinary Ophthalmology Annual Conference, Monterey, CA). As a result of this work, veterinary ophthalmologists worldwide can now diagnose dogs affected with SARDS at a much earlier stage of the disease.

Dogs diagnosed with SARDS that have normal day vision have an almost 80% chance of keeping their sight if timely medical treatment is initiated. Dogs with this disease have 100% risk of blindness if left untreated, or if treatment is not aggressive or timely.

Retinal toxicity of anti-parasitic medications

Dr. Grozdanić and his team are also looking at incidence of retinal toxicity in dogs treated with regular monthly heartworm medications containing ivermectin, and some novel anti-parasitic agents with prolonged delivery mechanism. Over the last five years, clinicians from Animal Eye Consultants of Iowa noticed a significant increase in the number of patients developing visual problems (night vision loss, intermittent night and day vision loss, depth-perception issues), which have been associated with the use of these drugs. In many of these patients, pupil light reflex abnormalities are the very first clinical symptom of the problem.

Study goals

The goal of the retinal screening study is to enroll approximately 100 general veterinary practices in Iowa, and screen 36,000 veterinary patients during the first year of the study in order to determine incidence of retina and optic nerve diseases, SARDS and heartworm/anti-parasitic medication toxicity in the general veterinary patient population.

Educational Videos

Instrument instruction use video

A short demonstration of how the screening instrument is used in a routine exam.

Interested in the study?

For more information about the study and how to participate, please get in touch with Animal Eye Consultants of Iowa.