Vaccination-Associated Uveitis

Infection with canine infectious hepatitis virus, CAV-1, or vaccination with live modified CAV-1 can cause uveitis and/or endotheliitis. The source states that this condition occurs in approximately 0.4% of vaccinated dogs and attributes it to immune-complex formation, an Arthus reaction, and proteolytic activity of polymorphonuclear cells. Clinically, corneal edema creates a bluish appearance of the eye, the aqueous humor becomes cloudy, and miosis is present. Bullous keratopathy, ulcerative keratitis, and secondary glaucoma may develop as complications.

Treatment

Diagnosis is based on clinical appearance and a history of recent vaccination. Nonsteroidal anti-inflammatory medications are used. Complications such as ulcerative keratitis and glaucoma must be treated appropriately.

Vaccination-associated uveitis. The bluish appearance of the eye is caused by corneal edema.

Adapted from the Atlas of Ocular Diseases in Dogs and Cats by Dr. Siniša D. Grozdanić and colleagues. © Animal Eye Consultants of Iowa. The text and clinical images on this page are original content from the authors' own clinical practice and research, and may not be reproduced, distributed, or repurposed without permission.

Think your pet may have vaccination-associated uveitis?

Early evaluation gives us the most treatment options and the best chance of preserving vision.